ORC1L monoclonal antibody, clone 7A7
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Specification
Product Description
Rat monoclonal antibody raised against ORC1L.
Immunogen
Human ORC1L.
Host
Rat
Reactivity
Human
Specificity
human ORC1L.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
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Gene Info — ORC1L
Entrez GeneID
4998Gene Name
ORC1L
Gene Alias
HSORC1, ORC1, PARC1
Gene Description
origin recognition complex, subunit 1-like (yeast)
Omim ID
601902Gene Ontology
HyperlinkGene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq
Other Designations
OTTHUMP00000009797|OTTHUMP00000009798|origin recognition complex 1|origin recognition complex, subunit 1|origin recognition complex, subunit 1, S. cerevisiae, homolog-like|replication control protein 1
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Interactome
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Pathway
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Publication Reference
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Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.
Schepers A, Ritzi M, Bousset K, Kremmer E, Yates JL, Harwood J, Diffley JF, Hammerschmidt W.
The EMBO Journal 2001 Aug; 20(16):4588.
Application:ChIP, WB, Human, A39 cells.
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Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.
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