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Last updated: 2016/11/27
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ORC1L monoclonal antibody, clone 7A7

  • Catalog # : MAB2489
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against ORC1L.
  • Immunogen:
  • Human ORC1L.
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Specificity:
  • human ORC1L.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 4998
  • Gene Name:
  • ORC1L
  • Gene Alias:
  • HSORC1,ORC1,PARC1
  • Gene Description:
  • origin recognition complex, subunit 1-like (yeast)
  • Gene Summary:
  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000009797,OTTHUMP00000009798,origin recognition complex 1,origin recognition complex, subunit 1,origin recognition complex, subunit 1, S. cerevisiae, homolog-like,replication control protein 1
  • Gene Pathway
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