HNRNPL monoclonal antibody, clone 4D11
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot for HNRNPL monoclonal antibody, clone 4D11 (Cat # MAB2485) on HeLa cell extracts.
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Specification
Product Description
Mouse monoclonal antibody raised against native HNRNPL.
Immunogen
Native purified human HNRNPL.
Host
Mouse
Theoretical MW (kDa)
65
Reactivity
Human, Mouse, Newt
Specificity
Detects a band of approximately 65 KDa. It cross reacts with mouse & newt.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
Western Blot (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot for HNRNPL monoclonal antibody, clone 4D11 (Cat # MAB2485) on HeLa cell extracts.Immunofluorescence
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HNRNPL
Entrez GeneID
3191Gene Name
HNRNPL
Gene Alias
FLJ35509, HNRPL, P/OKcl.14, hnRNP-L
Gene Description
heterogeneous nuclear ribonucleoprotein L
Omim ID
603083Gene Ontology
HyperlinkGene Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Publication Reference
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A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
Pinol-Roma S, Swanson MS, Gall JG, Dreyfuss G.
The Journal of Cell Biology 1989 Dec; 109(6 Pt 1):2575.
Application：IF, IP, WB-Ce, Human, HeLa, JW36 cells.
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A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
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