KPNA2 monoclonal antibody, clone 2G7
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Specification
Product Description
Rat monoclonal antibody raised against recombinant KPNA2.
Immunogen
Recombinant protein corresponding to amino acids 116-515 of human KPNA2.
Host
Rat
Reactivity
Human
Specificity
human KPNA2.
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — KPNA2
Entrez GeneID
3838Gene Name
KPNA2
Gene Alias
IPOA1, QIP2, RCH1, SRP1alpha
Gene Description
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Omim ID
600685Gene Ontology
HyperlinkGene Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
Other Designations
RAG cohort 1|importin alpha 1|importin alpha 2|importin-alpha-P1|karyopherin alpha 2|pendulin
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Interactome
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Disease
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Publication Reference
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Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.
Fischer N, Kremmer E, Lautscham G, Mueller-Lantzsch N, Grässer FA.
The Journal of Biological Chemistry 1997 Feb; 272(7):3999.
Application:WB-Tr, Human, Insect, HEK 293GP, SF158 cells.
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Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.
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