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Last updated: 2016/10/16
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KPNA2 monoclonal antibody, clone 2G7

  • Catalog # : MAB2475
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against recombinant KPNA2.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 116-515 of human KPNA2.
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Specificity:
  • human KPNA2.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 3838
  • Gene Name:
  • KPNA2
  • Gene Alias:
  • IPOA1,QIP2,RCH1,SRP1alpha
  • Gene Description:
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  • Gene Summary:
  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
  • Other Designations:
  • RAG cohort 1,importin alpha 1,importin alpha 2,importin-alpha-P1,karyopherin alpha 2,pendulin
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