PGR (phospho S162) monoclonal antibody, clone 1064/E2
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic phosphopeptide of PGR.
Immunogen
Synthetic phosphopeptide corresponding to amino acids 156-169 residues surrounding S162 of human PGR.
Sequence
ATQRVLS(PO3)PLMSRSG
Host
Mouse
Reactivity
Human, Mouse
Specificity
Phosphoserine 162 in human PGR (isoform B). Cross reacts with phosphoserine 163 in mouse progesterone receptor.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
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Gene Info — PGR
Entrez GeneID
5241Gene Name
PGR
Gene Alias
NR3C3, PR
Gene Description
progesterone receptor
Omim ID
607311Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
Narayanan R, Edwards DP, Weigel NL.
Molecular and Cellular Biology 2005 Apr; 25(8):2885.
Application:WB-Tr, Human, Cat0 cells.
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Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
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