PABPC1 monoclonal antibody, clone 10E10
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot for PABPC1 monoclonal antibody, clone 10E10 (Cat # MAB2465) on HeLa cell extracts (left lane).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant PABPC1.
Immunogen
Recombinant protein corresponding to human PABPC1.
Host
Mouse
Theoretical MW (kDa)
70
Reactivity
Chicken, Clawed frog, Human, Rabbit
Specificity
Detects a band of approximately 70 KDa.
Form
Liquid
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot for PABPC1 monoclonal antibody, clone 10E10 (Cat # MAB2465) on HeLa cell extracts (left lane).Immunofluorescence
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PABPC1
Entrez GeneID
26986Gene Name
PABPC1
Gene Alias
PAB1, PABP, PABP1, PABPC2, PABPL1
Gene Description
poly(A) binding protein, cytoplasmic 1
Omim ID
604679Gene Ontology
HyperlinkGene Summary
The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.[supplied by OMIM
Other Designations
poly(A) binding protein, cytoplasmic 2|poly(A)-binding protein, cytoplasmic 2
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Interactome
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Publication Reference
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Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein.
Kanno T, Sato Y, Sata T, Katano H.
Virology 2006 Aug; 352(1):100.
Application：IF, IP, WB, Human, BCBL-1, TY-1 cells.
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Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.
Hofmann I, Casella M, Schnolzer M, Schlechter T, Spring H, Franke WW.
Molecular Biology of the Cell 2006 Mar; 17(3):1388.
Application：IF, IP-WB, WB, Human, HaCaT cells.
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Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.
Baez MV, Boccaccio GL.
The Journal of Biological Chemistry 2005 Dec; 280(52):43131.
Application：IF, Monkey, COS-7 cells.
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Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein.
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