ATM (phospho S1981) monoclonal antibody, clone 10H11.E12
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic phosphopeptide of ATM.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S1981 of human ATM.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to the human ATM kinase.
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunocytochemistry (1:1000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.05% sodium azide
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ATM on irradiated or peroxidated human fibroblasts using ATM monoclonal antibody, clone 10H11.E12 (Cat # MAB2401).Immunocytochemistry
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Gene Info — ATM
Entrez GeneID
472Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactome
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Pathway
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Disease
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Publication Reference
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Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.
Bidyut K Mohanty, Joseph Aq Karam, Breege V Howley, Annamarie C Dalton, Simon Grelet, Toros Dincman, William S Streitfeld, Je-Hyun Yoon, Lata Balakrishnan, Walter J Chazin, David T Long, Philip H Howe.
Life Science Alliance 2021 Jul; 4(9):e202000995.
Application:WB, Human, Monkey, A549, NMuMG cells.
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HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S.
Cancer Research 2008 Dec; 68(23):9954.
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Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S.
The Journal of Biological Chemistry 2008 Sep; 283(37):25692.
Application:IF, Mouse, LSK cells.
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Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest.
Ye X, Franco AA, Santos H, Nelson DM, Kaufman PD, Adams PD.
Molecular Cell 2003 Feb; 11(2):341.
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Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.
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