RAD51L3 monoclonal antibody, clone 5B3/6
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant RAD51L3.
Immunogen
Recombinant His fusion protein corresponding to human RAD51L3.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to Rad51D.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Immunocytochemistry (1:100)
Immunofluorescence (1:500)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Western Blot (Cell lysate)
RAD51L3 detected in HEK293 lysates using a 1 : 1,000 dilution of RAD51L3 monoclonal antibody, clone 5B3/6 (Cat # MAB2395). Photo courtesy of B.T. Bennett & K. Knight of University of Massachusetts Medical School.Immunocytochemistry
Immunofluorescence
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Gene Info — RAD51L3
Entrez GeneID
5892Protein Accession#
O75771Gene Name
RAD51L3
Gene Alias
HsTRAD, R51H3, RAD51D, Trad
Gene Description
RAD51-like 3 (S. cerevisiae)
Omim ID
602954Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined. [provided by RefSeq
Other Designations
DNA repair protein RAD51 homolog 4|RAD51-like 3|recombination repair protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC.
Blood 2008 Dec; 113(10):2290.
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Repression of mutagenesis by Rad51D-mediated homologous recombination.
Hinz JM, Tebbs RS, Wilson PF, Nham PB, Salazar EP, Nagasawa H, Urbin SS, Bedford JS, Thompson LH.
Nucleic Acids Research 2006 Mar; 34(5):1358.
Application:WB-Ce, Mouse , CHO cells.
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Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG.
Cancer Research 2004 Dec; 64(23):8526.
Application:IHC, Human, Mouse, DU-145 cells, Mouse tumors, PC-3 cells.
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Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
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