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Last updated: 2017/2/19
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TERT monoclonal antibody, clone 2D8

  • Catalog # : MAB2379
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant TERT.
  • Immunogen:
  • Recombinant protein corresponding to full length human TERT.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to hTERT.
  • Form:
  • Liquid
  • Isotype:
  • IgM
  • Recommend Usage:
  • Flow Cytometry (1:50-1:200)
    Immunocytochemistry (1:50-1:200)
    Immunofluorescence (1:50-1:200)
    Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In buffer containing 0.09% sodium azide
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of human TERT using TERT monoclonal antibody, clone 2D8 (Cat # MAB2379). Sample : MJ90 whole cell lysate.
  • Immunocytochemistry
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunocytochemistry
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 7015
  • Gene Name:
  • TERT
  • Gene Alias:
  • EST2,TCS1,TP2,TRT,hEST2
  • Gene Description:
  • telomerase reverse transcriptase
  • Gene Summary:
  • Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq
  • Other Designations:
  • telomerase catalytic subunit
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