CASR monoclonal antibody, clone HL 1499
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant CASR.
Immunogen
Recombinant protein corresponding to N-terminus extracellular region of human CASR.
Host
Mouse
Reactivity
Human, Mouse, Rabbit, Rat
Specificity
This antibody is specific to Calcium Sensing Receptor protein.
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
ELISA (1:50-1:200)
Immunohistochemistry (Frozen sections) (1:50-1:200)
RadioEnzymeImmunoassay (1:50-1:200)
Western Blot (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Detection of CASR in transfected 293 cell lysate using CASR monoclonal antibody, clone HL 1499 (Cat #MAB2357).
In this photo, the protein has aggregated and thus the higher MW band as expected.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
Immunodiffusion
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Gene Info — CASR
Entrez GeneID
846Protein Accession#
P41180Gene Name
CASR
Gene Alias
CAR, FHH, FIH, GPRC2A, HHC, HHC1, MGC138441, NSHPT, PCAR1
Gene Description
calcium-sensing receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq
Other Designations
extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1
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Interactome
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Disease
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Publication Reference
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Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein.
Awata H, Huang C, Handlogten ME, Miller RT.
The Journal of Biological Chemistry 2001 Sep; 276(37):34871.
Application:IF, WB-Tr, Human, HEK-293 cells.
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Extracellular Ca(2+)-sensing receptor is a promiscuous divalent cation sensor that responds to lead.
Handlogten ME, Shiraishi N, Awata H, Huang C, Miller RT.
American Journal of Physiology. Renal Physiology 2000 Dec; 279(6):F1083.
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Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein.
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