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Last updated: 2016/11/27
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CASR monoclonal antibody, clone HL 1499

  • Catalog # : MAB2357
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant CASR.
  • Immunogen:
  • Recombinant protein corresponding to N-terminus extracellular region of human CASR.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse, Rabbit, Rat
  • Specificity:
  • This antibody is specific to Calcium Sensing Receptor protein.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • ELISA (1:50-1:200)
    Immunohistochemistry (Frozen sections) (1:50-1:200)
    RadioEnzymeImmunoassay (1:50-1:200)
    Western Blot (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Detection of CASR in transfected 293 cell lysate using CASR monoclonal antibody, clone HL 1499 (Cat #MAB2357).
    In this photo, the protein has aggregated and thus the higher MW band as expected.
  • Immunohistochemistry (Frozen sections)
  • ELISA
  • Immunodiffusion
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • ELISA
  • Immunodiffusion
  • Gene Information
  • Entrez GeneID:
  • 846
  • Gene Name:
  • CASR
  • Gene Alias:
  • CAR,FHH,FIH,GPRC2A,HHC,HHC1,MGC138441,NSHPT,PCAR1
  • Gene Description:
  • calcium-sensing receptor
  • Gene Summary:
  • The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq
  • Other Designations:
  • extracellular calcium-sensing receptor,parathyroid Ca(2+)-sensing receptor 1
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