CUGBP1 monoclonal antibody, clone 3B1
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot Analysis detection of CUGBP1 in several cell lysates using CUGBP1 monoclonal antibody, clone 3B1 (Cat #MAB2351).
Immunofluorescence
Detection of the subcellular distribution of CUGBP1 (nuclear, non-nucleolar) in normal and DM1 (dystrophia myotonica)
myoblasts using CUGBP1 monoclonal antibody, clone 3B1 (Cat #MAB2351).
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Specification
Product Description
Mouse monoclonal antibody raised against CUGBP1.
Immunogen
Human CUGBP1.
Host
Mouse
Reactivity
Bovine, Human, Mouse, Pig, Rabbit, Rat
Specificity
This antibody is specific to human CUG-BP1.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.09% sodium azide
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot Analysis detection of CUGBP1 in several cell lysates using CUGBP1 monoclonal antibody, clone 3B1 (Cat #MAB2351).Immunofluorescence
Detection of the subcellular distribution of CUGBP1 (nuclear, non-nucleolar) in normal and DM1 (dystrophia myotonica)
myoblasts using CUGBP1 monoclonal antibody, clone 3B1 (Cat #MAB2351). -
Gene Info — CUGBP1
Entrez GeneID
10658Protein Accession#
Q92879Gene Name
CUGBP1
Gene Alias
BRUNOL2, CUG-BP, CUGBP, NAB50, hNab50
Gene Description
CUG triplet repeat, RNA binding protein 1
Omim ID
601074Gene Ontology
HyperlinkGene Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
CUG RNA-binding protein|CUG triplet repeat, RNA-binding protein 1|bruno-like 2|nuclear polyadenylated RNA-binding protein, 50-kD
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Interactome
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Publication Reference
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Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice.
Kress C, Gautier-Courteille C, Osborne HB, Babinet C, Paillard L.
Molecular Biology of the Cell 2007 Feb; 27(3):1146.
Application：IHC-P, WB, Mouse, Mouse fibroblasts, testis.
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Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Timchenko LT, Miller JW, Timchenko NA, DeVore DR, Datar KV, Lin L, Roberts R, Caskey CT, Swanson MS.
Nucleic Acids Research 1996 Nov; 24(22):4407.
Application：IF, IP, WB-Ce, Chicken, Mouse, Human, Rabbit, Yeast, BJ926, CEF, HeLa, NIH/3T3, RK13, XL1 cells.
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Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice.
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