MAP2K4 (phospho S257) monoclonal antibody, clone C5 (PE)
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More Files
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Flow Cytometry
Flow cytometric analysis of HEK 293T cells with MAP2K4 (phospho S257) monoclonal antibody, clone C5 (PE) (Cat # MAB23473). Unstained and untreated cells as negative control (blue) or treated with lambda phosphatase (red) or treated with UV (100 mJ/cm^2)+TPA (200nM, 1 hr recovery ; green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAP2K4.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S257 of human MAP2K4.
Host
Rabbit
Reactivity
Human, Macaque, Mouse
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of HEK 293T cells with MAP2K4 (phospho S257) monoclonal antibody, clone C5 (PE) (Cat # MAB23473). Unstained and untreated cells as negative control (blue) or treated with lambda phosphatase (red) or treated with UV (100 mJ/cm^2)+TPA (200nM, 1 hr recovery ; green). -
Gene Info — MAP2K4
Entrez GeneID
6416Gene Name
MAP2K4
Gene Alias
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
Gene Description
mitogen-activated protein kinase kinase 4
Omim ID
601335Gene Ontology
HyperlinkGene Summary
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq
Other Designations
JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4
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Interactome
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Disease
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