PTPN11 (phospho Y580) monoclonal antibody, clone 4A2 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of U-937 cells with PTPN11 (phospho Y580) monoclonal antibody, clone 4A2 (APC) (Cat # MAB2337). Unstained and untreated as negative control (blue) or stained and untreated (red) or stained and treated with IFNa plus IL-4 and pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PTPN11.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y580 of human PTPN11.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
APC
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of U-937 cells with PTPN11 (phospho Y580) monoclonal antibody, clone 4A2 (APC) (Cat # MAB2337). Unstained and untreated as negative control (blue) or stained and untreated (red) or stained and treated with IFNa plus IL-4 and pervanadate (green). -
Gene Info — PTPN11
Entrez GeneID
5781Gene Name
PTPN11
Gene Alias
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Description
protein tyrosine phosphatase, non-receptor type 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
Other Designations
protein tyrosine phosphatase-2|protein-tyrosine phosphatase 2C
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Interactome
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Disease
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