RB1 (phospho S807/S811) monoclonal antibody, clone D9 (SureLight 488)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of U-937 cells with RB1 (phospho S807/S811) monoclonal antibody, clone D9 (SureLight 488) (Cat # MAB23427). Untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human RB1.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S807/S811 of human RB1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
SureLight 488
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of U-937 cells with RB1 (phospho S807/S811) monoclonal antibody, clone D9 (SureLight 488) (Cat # MAB23427). Untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red). -
Gene Info — RB1
Entrez GeneID
5925Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
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Interactome
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Pathway
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Disease
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