MAP3K5 (phospho T838) monoclonal antibody, clone 8D12 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of NIH3T3 cells with MAP3K5 (phospho Thr838) monoclonal antibody, clone 8D12 (APC)(Cat # MAB23359). Unstained as negative control (blue) or treated with staurosporine (red) or with PDGF (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAP3K5.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr838 of human phospho Ask1
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
APC
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/million cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% NaN3, 0.2% BSA)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of NIH3T3 cells with MAP3K5 (phospho Thr838) monoclonal antibody, clone 8D12 (APC)(Cat # MAB23359). Unstained as negative control (blue) or treated with staurosporine (red) or with PDGF (green). -
Gene Info — MAP3K5
Entrez GeneID
4217Protein Accession#
Q99683Gene Name
MAP3K5
Gene Alias
ASK1, MAPKKK5, MEKK5
Gene Description
mitogen-activated protein kinase kinase kinase 5
Omim ID
602448Gene Ontology
HyperlinkGene Summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq
Other Designations
MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|OTTHUMP00000017275|apoptosis signal regulating kinase
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Interactome
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Disease
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