JAK1 (phospho Tyr1022/1023) monoclonal antibody, clone F11 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of Jurkat cells with JAK1 monoclonal antibody, clone F11 (FITC)(Cat # MAB23348). Unstained as negative control (blue) or untreated (red) or treated with IFNα + IL-4 + pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human JAK1.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
FITC
Recommend Usage
Flow Cytometry (5 uL/million cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% NaN3, 0.2% BSA)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells with JAK1 monoclonal antibody, clone F11 (FITC)(Cat # MAB23348). Unstained as negative control (blue) or untreated (red) or treated with IFNα + IL-4 + pervanadate (green). -
Gene Info — JAK1
Entrez GeneID
3716Protein Accession#
P23458Gene Name
JAK1
Gene Alias
JAK1A, JAK1B, JTK3
Gene Description
Janus kinase 1 (a protein tyrosine kinase)
Omim ID
147795Gene Ontology
HyperlinkGene Summary
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq
Other Designations
OTTHUMP00000010896|janus kinase 1
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