DEFA5 monoclonal antibody, clone 8C8
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More Files
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Immunohistochemistry
Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining using DEFA5 monoclonal antibody, clone 8C8 (Cat # MAB2329).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant DEFA5.
Immunogen
Recombinant protein corresponding to full length human DEFA5.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to HD5. It does not cross-react with HD6, lysozyme or sPLA2.
Form
Liquid
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against DEFA5.
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining using DEFA5 monoclonal antibody, clone 8C8 (Cat # MAB2329).Immunofluorescence
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Gene Info — DEFA5
Entrez GeneID
1670Protein Accession#
Q01523Gene Name
DEFA5
Gene Alias
DEF5, HD-5, MGC129728
Gene Description
defensin, alpha 5, Paneth cell-specific
Omim ID
600472Gene Ontology
HyperlinkGene Summary
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq
Other Designations
defensin 5|defensin, alpha 5|defensin, alpha 5, preproprotein
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Interactome
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Disease
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Publication Reference
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Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.
Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL.
FEBS Letters 2006 Oct; 580(22):5344.
Application：IF, IHC-P, Human, Duodenal mucosa.
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Reduced Paneth cell alpha-defensins in ileal Crohn's disease.
Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL.
PNAS 2005 Dec; 102(50):18129.
Application：WB-Ti, Human, Ileal mucosa.
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Localization of human intestinal defensin 5 in Paneth cell granules.
Porter EM, Liu L, Oren A, Anton PA, Ganz T.
Infection and Immunity 1997 Jun; 65(6):2389.
Application：Dot, ELISA, IEM, IHC-P, WB, Human, Human small intestines.
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Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.
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