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DEFA5 monoclonal antibody, clone 8C8

  • Catalog # : MAB2329
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant DEFA5.
  • Immunogen:
  • Recombinant protein corresponding to full length human DEFA5.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to HD5. It does not cross-react with HD6, lysozyme or sPLA2.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Quality Control Testing:
  • Antibody Reactive Against DEFA5.
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 2.
  • Reduced Paneth cell alpha-defensins in ileal Crohn's disease.
    Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL.Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18129-34. Epub 2005 Dec 5.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry
  • Immunohistochemistry
  • Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining using DEFA5 monoclonal antibody, clone 8C8 (Cat # MAB2329).
  • Immunofluorescence
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 1670
  • Gene Name:
  • DEFA5
  • Gene Alias:
  • DEF5,HD-5,MGC129728
  • Gene Description:
  • defensin, alpha 5, Paneth cell-specific
  • Gene Summary:
  • Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq
  • Other Designations:
  • defensin 5,defensin, alpha 5,defensin, alpha 5, preproprotein
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