C4A monoclonal antibody, clone A24-T
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with C4A monoclonal antibody, clone A24-T (Cat # MAB23287).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human C4A.
Immunogen
A synthetic peptide corresponding to internal region of human C4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
immunoaffinity purification
Recommend Usage
Immunohistochemistry (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl buffer, pH 8.0 (20 mg/mL BSA, 0.05% Sodium Azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with C4A monoclonal antibody, clone A24-T (Cat # MAB23287). -
Gene Info — C4A
Entrez GeneID
720Protein Accession#
P0C0L4Gene Name
C4A
Gene Alias
C4, C4A2, C4A3, C4A4, C4A6, C4S, CO4, CPAMD2, MGC164979, RG
Gene Description
complement component 4A (Rodgers blood group)
Omim ID
120810Gene Ontology
HyperlinkGene Summary
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. [provided by RefSeq
Other Designations
C4A anaphylatoxin|OTTHUMP00000029266|Rodgers form of C4|acidic C4|complement component 4A
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Interactome
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Pathway
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Disease
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