TNFRSF8 monoclonal antibody, clone RM425
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human TNFRSF8.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to the C-terminus of human TNFRSF8.
Reactivity
Human
Specificity
This antibody reacts to human TNFRSF8.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunochemistry (1:100 - 1:250)
Western Blot (1:1000 - 1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot of K562 cell lysate using TNFRSF8 monoclonal antibody clone RM425 at a 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human Hodgkin's lymphoma tissue section using TNFRSF8 monoclonal antibody clone RM425 at a 1:100 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using TNFRSF8 monoclonal antibody clone RM425 at a 1:100 dilution. -
Gene Info — TNFRSF8
Entrez GeneID
943Gene Name
TNFRSF8
Gene Alias
CD30, D1S166E, KI-1
Gene Description
tumor necrosis factor receptor superfamily, member 8
Omim ID
153243Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD30 antigen|CD30L receptor|Ki-1 antigen|OTTHUMP00000001783|cytokine receptor CD30|lymphocyte activation antigen CD30
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