ZAP70 monoclonal antibody, clone RM408
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot of Jurkat cell lysate using ZAP70 monoclonal antibody clone RM408 at a 1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using ZAP70 monoclonal antibody clone RM408 at a 1:200 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ZAP70.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to N-terminus of human ZAP70.
Reactivity
Human
Specificity
This antibody reacts to human ZAP70. This antibody may also react to mouse or rat Zap70, as predicted by immunogen homology.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunochemistry (1:100 - 1:200)
Western Blot (1:500 - 1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot of Jurkat cell lysate using ZAP70 monoclonal antibody clone RM408 at a 1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using ZAP70 monoclonal antibody clone RM408 at a 1:200 dilution. -
Gene Info — ZAP70
Entrez GeneID
7535Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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