ANPEP monoclonal antibody, clone RM403
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot of HepG2 cells lysate using ANPEP monoclonal antibody clone RM403 at a 1:2000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human liver section using ANPEP monoclonal antibody clone RM403 at a 1:200 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ANPEP.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to C-terminus of human ANPEP.
Reactivity
Human
Specificity
This antibody reacts to human ANPEP.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunochemistry (1:100 - 1:200)
Western Blot (1:1000 - 1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot of HepG2 cells lysate using ANPEP monoclonal antibody clone RM403 at a 1:2000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human liver section using ANPEP monoclonal antibody clone RM403 at a 1:200 dilution. -
Gene Info — ANPEP
Entrez GeneID
290Gene Name
ANPEP
Gene Alias
APN, CD13, LAP1, PEPN, gp150, p150
Gene Description
alanyl (membrane) aminopeptidase
Omim ID
151530Gene Ontology
HyperlinkGene Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
Other Designations
OTTHUMP00000194690|aminopeptidase M|aminopeptidase N|membrane alanine aminopeptidase|microsomal aminopeptidase
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Interactome
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Pathway
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Disease
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