Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with CHGA monoclonal antibody, clone RM385 (Cat # MAB23167) at a 1:2500 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with CHGA monoclonal antibody, clone RM385 (Cat # MAB23167) at a 1:10000 dilution.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq
Other Designations:
betagranin (N-terminal fragment of chromogranin A),chromogranin A,parathyroid secretory protein 1