MMP12 monoclonal antibody, clone RM381
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HEK 293 cell lysates with MMP12 monoclonal antibody, clone RM381 (Cat # MAB23163) at a 1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung with MMP12 monoclonal antibody, clone RM381 (Cat # MAB23163) at a 1:2500 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MMP12.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to C-terminus of human MMP12.
Reactivity
Human
Specificity
This antibody reacts to human MMP12.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:1000-1:2500)
Western Blot (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HEK 293 cell lysates with MMP12 monoclonal antibody, clone RM381 (Cat # MAB23163) at a 1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung with MMP12 monoclonal antibody, clone RM381 (Cat # MAB23163) at a 1:2500 dilution. -
Gene Info — MMP12
Entrez GeneID
4321Gene Name
MMP12
Gene Alias
HME, MGC138506, MME
Gene Description
matrix metallopeptidase 12 (macrophage elastase)
Omim ID
601046Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
macrophage elastase|macrophage metalloelastase|matrix metalloproteinase 12|matrix metalloproteinase 12 (macrophage elastase)
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Interactome
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Disease
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