Anti-Rituximab monoclonal antibody, clone 6C1
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More Files
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Enzyme-linked Immunoabsorbent Assay
Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) binds with Rituximab. Coating antigen: Rituximab, 1 ug/mL. Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) dilution start from 2000 ng/mL. EC50 = 7.819 ng/mL. While the antibody does not recognize the human IgG (data not shown).
Sandwich ELISA
Standard curve of Rituximab Sandwich ELISA. The Rituximab Sandwich ELISA assay is developed by using Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) and Anti-Rituximab monoclonal antibody, clone 17B6 (Cat # MAB23137) as the capture and detection antibodies, respectively. In this ELISA assay, Anti-Rituximab monoclonal antibody, clone 17B6 (Cat # MAB23137) was labeled with Biotin. The sensitivity is less than 1 ng/mL.
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Specification
Product Description
Mouse monoclonal antibody raised against Rituximab.
Target gene is CD20.Immunogen
Rituximab.
Host
Mouse
Specificity
The product is specific for Rituximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody Anti-Rituximab monoclonal antibody, clone 17B6 (Cat # MAB23137).
Form
Lyophilized
Preparation Method
This antibody is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Rituximab.
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
ELISA (ELISA detection: 0.01-0.1 ug/mL) (Direct/Indirect ELISA)
Sandwich ELISA
The optimal working dilution should be determined by the end user.Inhibitory IC50
Non-inhibitory
Storage Buffer
Lyophilized from PBS, pH 7.4 (0.02% sodium azide).
Storage Instruction
Store at -20°C on dry atmosphere, lyophilized antibodies are stable at 1 years.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) binds with Rituximab. Coating antigen: Rituximab, 1 ug/mL. Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) dilution start from 2000 ng/mL. EC50 = 7.819 ng/mL. While the antibody does not recognize the human IgG (data not shown).Sandwich ELISA
Standard curve of Rituximab Sandwich ELISA. The Rituximab Sandwich ELISA assay is developed by using Anti-Rituximab monoclonal antibody, clone 6C1 (Cat # MAB23136) and Anti-Rituximab monoclonal antibody, clone 17B6 (Cat # MAB23137) as the capture and detection antibodies, respectively. In this ELISA assay, Anti-Rituximab monoclonal antibody, clone 17B6 (Cat # MAB23137) was labeled with Biotin. The sensitivity is less than 1 ng/mL. -
Gene Info — MS4A1
Entrez GeneID
931Gene Name
MS4A1
Gene Alias
B1, Bp35, CD20, LEU-16, MGC3969, MS4A2, S7
Gene Description
membrane-spanning 4-domains, subfamily A, member 1
Omim ID
112210Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq
Other Designations
B-lymphocyte cell-surface antigen B1|CD20 antigen|CD20 receptor
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Interactome
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Pathway
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Disease
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