Anti-Ipilimumab monoclonal antibody, clone 4H6 (Biotin)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Anti-Ipilimumab monoclonal antibody, clone 4H6 (Biotin) (Cat # MAB23078) binds with Ipilimumab, while the antibody does not recognize human IgG Fc fragment (data not shown). Coating antigen: Ipilimumab, 1 ug/mL. Anti-Ipilimumab monoclonal antibody, clone 4H6 (Biotin) (Cat # MAB23078) dilution start from 1000 ng/mL. EC50 =3.85 ng/mL.
-
Specification
Product Description
Mouse monoclonal antibody raised against Ipilimumab.
Target gene is CTLA-4.Immunogen
Ipilimumab.
Host
Mouse
Specificity
The product is specific for Ipilimumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody Anti-Ipilimumab monoclonal antibody, clone 26B6H7D9 (Cat # MAB23076).
Form
Lyophilized
Conjugation
Biotin
Preparation Method
This antibody is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Ipilimumab.
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
ELISA (ELISA detection: 0.01-0.1 ug/mL) (Direct/Indirect ELISA)
The optimal working dilution should be determined by the end user.Inhibitory IC50
Non-inhibitory
Storage Buffer
Lyophilized from PBS, pH 7.4 (1% BSA, 0.02% sodium azide).
Storage Instruction
Store at -20°C. The lyophilized product remains stable up to 1 year at -20°C from date of receipt.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Enzyme-linked Immunoabsorbent Assay
Anti-Ipilimumab monoclonal antibody, clone 4H6 (Biotin) (Cat # MAB23078) binds with Ipilimumab, while the antibody does not recognize human IgG Fc fragment (data not shown). Coating antigen: Ipilimumab, 1 ug/mL. Anti-Ipilimumab monoclonal antibody, clone 4H6 (Biotin) (Cat # MAB23078) dilution start from 1000 ng/mL. EC50 =3.85 ng/mL. -
Gene Info — CTLA4
Entrez GeneID
1493Gene Name
CTLA4
Gene Alias
CD152, CELIAC3, CTLA-4, GSE, IDDM12
Gene Description
cytotoxic T-lymphocyte-associated protein 4
Gene Ontology
HyperlinkGene Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq
Other Designations
OTTHUMP00000163781|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com