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CD209 monoclonal antibody, clone ARC1679 

  • Catalog # : MAB23066
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human CD209.
  • Immunogen:
  • A synthetic peptide corresponding to human CD209.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 50
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:50-1:200)
    Immunohistochemistry (1:50-1:200)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (0.05% BSA, 50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Lane 1: HepG2, Lane 2: A-549, Lane 3: THP-1 using CD209 monoclonal antibody, clone ARC1679 (Cat # MAB23066) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of rat spleen using CD209 monoclonal antibody, clone ARC1679 (Cat # MAB23066) at dilution of 1:100 (40x lens).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of Raw 264.7 cells using CD209 monoclonal antibody, clone ARC1679 (Cat # MAB23066) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of THP-1 cells using CD209 monoclonal antibody, clone ARC1679 (Cat # MAB23066) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • CD209
  • Gene Alias:
  • CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,MGC129965
  • Gene Description:
  • CD209 molecule
  • Gene Summary:
  • This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants
  • Other Designations:
  • C-type lectin domain family 4, member L,CD209 antigen,Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
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