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Last updated: 2021/10/17

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RPE65 monoclonal antibody, clone ARC1659 

  • Catalog # : MAB23058
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human RPE65.
  • Immunogen:
  • A synthetic peptide corresponding to human RPE65.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 61
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:50-1:200)
    Immunohistochemistry (1:50-1:200)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (0.05% BSA, 50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of rat eye using RPE65 monoclonal antibody, clone ARC1659 (Cat # MAB23058) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of rat retina using RPE65 monoclonal antibody, clone ARC1659 (Cat # MAB23058) at dilution of 1:100 (40x lens).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of mouse retina using RPE65 monoclonal antibody, clone ARC1659 (Cat # MAB23058) at dilution of 1:100 (40x lens).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of rat eye using RPE65 monoclonal antibody, clone ARC1659 (Cat # MAB23058) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of mouse eye using RPE65 monoclonal antibody, clone ARC1659 (Cat # MAB23058) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 6121
  • Gene Name:
  • RPE65
  • Gene Alias:
  • LCA2,RP20,mRPE65,rd12,sRPE65
  • Gene Description:
  • retinal pigment epithelium-specific protein 65kDa
  • Gene Summary:
  • This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000010788,RBP-binding membrane protein,p63,retinal pigment epithelium-specific 61 kDa protein,retinal pigment epithelium-specific protein (65kD),retinitis pigmentosa 20 (autosomal recessive)
  • Gene Pathway
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