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SPTA1 monoclonal antibody, clone ARC1650 

  • Catalog # : MAB23051
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human SPTA1.
  • Immunogen:
  • A synthetic peptide corresponding to human SPTA1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 280
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (0.05% BSA, 50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western Blot analysis of extracts of various cell lines and tissues. Lane 1: K-562, Lane 2: mouse lung, and Lane 3: rat heart. Primary antibody: at 1:1000 dilution.
    Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
    Lysates/proteins: 25 ug per lane.
    Blocking buffer: 3% nonfat dry milk in TBST.
    Detection: ECL Basic Kit.
    Exposure time: 10 s.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 6708
  • Gene Name:
  • SPTA1
  • Gene Alias:
  • EL2,SPTA
  • Gene Description:
  • spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
  • Gene Summary:
  • Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000021115,alpha-I spectrin,erythrocyte alpha-spectrin,erythroid alpha-spectrin,spectrin alpha chain, erythrocyte,spectrin, alpha, erythrocytic 1
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