Western blot analysis of Lane 1: HeLa, Lane 2: 293T, Lane 3: HepG2 , Lane 4: mouse liver, Lane 5: mouse spleen, Lane 6: mouse kidney, Lane 7: rat liver using HOXA13 monoclonal antibody, clone ARC1636 (Cat # MAB23048) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq
Other Designations:
homeo box 1J,homeo box A13,homeobox protein HOXA13,transcription factor HOXA13