NOD2 monoclonal antibody, clone 2D9
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant NOD2.
Immunogen
Recombinant protein corresponding to amino acids 28-301 of human NOD2.
Host
Mouse
Theoretical MW (kDa)
110
Reactivity
Human, Mouse
Specificity
This antibody is specific to NOD2 protein.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NOD2 in 50 ug of HT-29 cell lysate with NOD2 monoclonal antibody, clone 2D9 (Cat # MAB2303).Western Blot (Transfected lysate)
Western blot analysis of NOD2 in NOD2 transfected HEK 293T (Bosc 23) cell lysate with NOD2 monoclonal antibody, clone 2D9 (Cat # MAB2303).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
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Gene Info — NOD2
Entrez GeneID
64127Gene Name
NOD2
Gene Alias
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Gene Description
nucleotide-binding oligomerization domain containing 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq
Other Designations
NLR family, CARD domain containing 2|NOD-like receptor C2|OTTHUMP00000164224|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-bin
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Interactome
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Disease
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Publication Reference
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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nunez G.
Gut 2003 Nov; 52(11):1591.
Application:IHC-P, WB, Human, HEK 293T, HL-60 cells, Uninvolved terminal ileum.
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Crohn's disease and the NOD2 gene: a role for paneth cells.
Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nunez G, Keshav S.
Gastroenterology 2003 Jul; 125(1):47.
Application:IHC-P, Human, Paneth cells in small intestinal crypts.
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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
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