RAD21 monoclonal antibody, clone CM110-2C10
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant RAD21.
Immunogen
Recombinant protein corresponding to amino acids 544-631 of human RAD21.
Host
Mouse
Reactivity
Human, Mouse
Specificity
This antibody is specific to both the nuclear hRad21 protein and the cleaved cytoplasmic hRad21 protein.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RAD21 in 293 cell lysates with RAD21 monoclonal antibody, clone CM110-2C10 (Cat # MAB2300). -
Gene Info — RAD21
Entrez GeneID
5885Gene Name
RAD21
Gene Alias
FLJ25655, FLJ40596, HR21, HRAD21, KIAA0078, MCD1, NXP1, SCC1, hHR21
Gene Description
RAD21 homolog (S. pombe)
Omim ID
606462Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq
Other Designations
RAD21 homolog|nuclear matrix protein 1|protein involved in DNA double-strand break repair
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Interactome
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Pathway
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Disease
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Publication Reference
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Linking sister chromatid cohesion and apoptosis: role of Rad21.
Pati D, Zhang N, Plon SE.
Molecular and Cellular Biology 2002 Dec; 22(23):8267.
Application:IF, IP-WB, WB-Ce, Human, Molt4, JEG3, MCF-7, ML-1, HL-60 cells.
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Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres.
Hoque MT, Ishikawa F.
The Journal of Biological Chemistry 2001 Feb; 276(7):5059.
Application:IF, IP, WB, Human, HeLa cells.
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Linking sister chromatid cohesion and apoptosis: role of Rad21.
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