Western blot analysis of Lane 1: 293T cell lysate, Lane 2: A-549 cell lysate, Lane 3: mouse brain tissue lysate, Lane 4: rat lung tissue lysate using CAPNS1 monoclonal antibody, clone ARC1326 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations:
calcium-activated neutral proteinase,calcium-dependent protease, small subunit,calpain 4, small subunit (30K),calpain, small polypeptide