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Immunohistochemistry (Frozen sections)

Flow Cytometry

Five x 10⁵ cultured human Molt-4 cells per tube were incubated 45 minutes on ice with 80 uL anti-CD1c antibody at 10 ug/mL. Cells were washed twice and incubated with secondary reagent goat anti-mouse IgG/FITC at a 1:60 dilution factor, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.45 log₁₀ fluorescent units when compared to a mouse IgG1 negative control at a similar concentration.

Entrez GeneID

911

Gene Name

CD1C

Gene Alias

BDCA1, CD1, CD1A, R7

Gene Description

CD1c molecule

Omim ID

188340

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq

Other Designations

CD1C antigen|CD1C antigen, c polypeptide|OTTHUMP00000018909|T-cell surface glycoprotein CD1c|cortical thymocyte antigen CD1C|differentiation antigen CD1-alpha-3