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CYP17A1 monoclonal antibody, clone ARC1257 

  • Catalog # : MAB22898
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human CYP17A1.
  • Immunogen:
  • A synthetic peptide corresponding to human CYP17A1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1:500-1:2000)
    Immunofluorescence (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (0.05% BSA, 50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western Blot analysis of (1) PC-3, (2) U-87MG cell lysates, (3) mouse liver.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining of HeLa cells. Blue: DAPI for nuclear staining.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 1586
  • Gene Name:
  • CYP17A1
  • Gene Alias:
  • CPT7,CYP17,P450C17,S17AH
  • Gene Description:
  • cytochrome P450, family 17, subfamily A, polypeptide 1
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020382,cytochrome P450, family 17,cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia,cytochrome p450 XVIIA1,steroid 17-alpha-hydroxylase/17,20 lyase,steroid 17-alpha-monooxygenase
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