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COPS5 monoclonal antibody, clone ARC0895 

  • Catalog # : MAB22833
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human COPS5.
  • Immunogen:
  • A synthetic peptide corresponding to human COPS5.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 38
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:50-1:200)
    Immunohistochemistry (1:50-1:200)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of Lane 1: HeLa cell lysate, Lane 2: 293T cell lysate, Lane 3: mouse testis tissue lysate, Lane 4: mouse kidney tissue lysate, Lane 5: rat testis tissue lysate, Lane 6: rat brain tissue lysate, using COPS5 monoclonal antibody, clone ARC0895 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry of (A) rat testis, (B) human colon, (C) mouse testis using COPS5 monoclonal antibody, clone ARC0895 at dilution of 1:100 (40x lens).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence analysis of NIH-3T3 cells using COPS5 monoclonal antibody, clone ARC0895 at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • COPS5
  • Gene Alias:
  • CSN5,JAB1,MGC3149,MOV-34,SGN5
  • Gene Description:
  • COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
  • Gene Summary:
  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq
  • Other Designations:
  • 38 kDa Mov34 homolog,COP9 signalosome subunit 5,Jun activation domain-binding protein
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