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AKR1C3 monoclonal antibody, clone ARC0857 

  • Catalog # : MAB22814
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human AKR1C3.
  • Immunogen:
  • A synthetic peptide corresponding to human AKR1C3.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 37
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:50-1:200)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of Lane 1: HepG2 cell lysate, Lane 2: mouse liver tissue lysate, using AKR1C3 monoclonal antibody, clone ARC0857 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence analysis of Hep G2 cells using AKR1C3 monoclonal antibody, clone ARC0857 at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 8644
  • Gene Name:
  • AKR1C3
  • Gene Alias:
  • DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,KIAA0119,hluPGFS
  • Gene Description:
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
  • Gene Summary:
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000018996,aldo-keto reductase family 1, member C3,chlordecone reductase,dihydrodiol dehydrogenase 3,dihydrodiol dehydrogenase X,hydroxysteroid (17-beta) dehydrogenase 5,prostaglandin F synthase,trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,type
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