Mouse Anti-Human (lambda chain) secondary antibody, clone JDC-12 (FITC)
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More Files
- More Functions
Fluorescence-linked Immunosorbent Assay
FLISA plate was coated with purified human IgG kappa, IgM kappa, IgA kappa, IgG lambda, IgM lambda, and IgA lambda. Immunoglobulins were detected with serially diluted Mouse Anti-Human (lambda chain) secondary antibody, clone JDC-12 (FITC).
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Specification
Product Description
Mouse monoclonal antibody raised against human lambda light chain.
Immunogen
Human lambda light chain.
Host
Mouse
Reactivity
Human
Specificity
Human/rhesus lambda.
Form
Liquid
Conjugation
FITC
Purification
Precipitation method and/or chromatography purification
Isotype
IgG1, kappa
Recommend Usage
ELISA (1:200-400)
Flow Cytometry (<= 1 ug/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Fluorescence-linked Immunosorbent Assay
FLISA plate was coated with purified human IgG kappa, IgM kappa, IgA kappa, IgG lambda, IgM lambda, and IgA lambda. Immunoglobulins were detected with serially diluted Mouse Anti-Human (lambda chain) secondary antibody, clone JDC-12 (FITC). -
Gene Info — IGL@
Entrez GeneID
3535Protein Accession#
P0CG04; P0DOY2; P0DOY3; A0M8Q6Gene Name
IGL@
Gene Alias
IGL, MGC88804
Gene Description
immunoglobulin lambda locus
Gene Ontology
HyperlinkGene Summary
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq
Other Designations
immunoglobulin lambda gene cluster
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