UHRF1 monoclonal antibody (AF594)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human UHRF1.
Immunogen
Recombinant protein corresponding to amino acids 1-408 at the N-terminus of human UHRF1.
Host
Mouse
Reactivity
Human
Form
Liquid
Conjugation
AF594
Conjugation Note
Excitation Emission: 591nm / 614nm
Storage Buffer
In 0.01 M Na3PO4, 0.25 M NaCl, pH 7.6 (5 mg/mL BSA, 0.02% sodium azide).
Storage Instruction
Store in the dark at 4°C for six months.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — UHRF1
Entrez GeneID
29128Protein Accession#
Q96T88Gene Name
UHRF1
Gene Alias
FLJ21925, ICBP90, MGC138707, Np95, RNF106, hNP95
Gene Description
ubiquitin-like with PHD and ring finger domains 1
Omim ID
607990Gene Ontology
HyperlinkGene Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
E3 ubiquitin-protein ligase UHRF1|RING finger protein 106|inverted CCAAT box-binding protein of 90 kDa|nuclear zinc finger protein Np95|transcription factor ICBP90|ubiquitin-like, containing PHD and RING finger domains, 1
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Interactome
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Disease
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