LMAN1 monoclonal antibody, clone AEBI-12
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More Files
- More Functions
Western Blot
Western Blot analysis of (1) HeLa , (2) Jurkat cell lysates.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human LMAN1.
Immunogen
A synthetic peptide corresponding to human LMAN1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with human, mouse, rat LMAN1, in native form and recombinant. Superfamily members of LMAN1 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1:50-200)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) HeLa , (2) Jurkat cell lysates.Immunofluorescence
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Gene Info — LMAN1
Entrez GeneID
3998Protein Accession#
P49257Gene Name
LMAN1
Gene Alias
ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58
Gene Description
lectin, mannose-binding, 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq
Other Designations
coagulation factor V-factor VIII combined deficiency|endoplasmic reticulum-golgi intermediate compartment protein 53|intracellular mannose specific lectin
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Interactome
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Disease
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