KLKB1 monoclonal antibody, clone ACDB-11
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of human plasma lysate.
-
Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human KLKB1.
Immunogen
A synthetic peptide corresponding to human KLKB1.
Host
Rabbit
Reactivity
Human
Specificity
The antibody reacts with human KLKB1, in native form and recombinant. Superfamily members of KLKB1 are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of human plasma lysate.Immunohistochemistry
Immunoprecipitation
-
Gene Info — KLKB1
Entrez GeneID
3818Protein Accession#
P03952Gene Name
KLKB1
Gene Alias
KLK3, PPK
Gene Description
kallikrein B, plasma (Fletcher factor) 1
Omim ID
229000Gene Ontology
HyperlinkGene Summary
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq
Other Designations
Kallikrein, plasma|kallikrein 3, plasma|kallikrein B plasma|kininogenin|plasma kallikrein B1
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com