SPTA1 monoclonal antibody, clone AFGF-19
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of SPTA1 in K-562 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human SPTA1.
Immunogen
A synthetic peptide corresponding to human SPTA1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with humant SPTA1, in native form and recombinant. Superfamily members of SPTA1 are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of SPTA1 in K-562 cell lysate.Immunohistochemistry
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Gene Info — SPTA1
Entrez GeneID
6708Protein Accession#
P02549Gene Name
SPTA1
Gene Alias
EL2, SPTA
Gene Description
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Ontology
HyperlinkGene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
Other Designations
OTTHUMP00000021115|alpha-I spectrin|erythrocyte alpha-spectrin|erythroid alpha-spectrin|spectrin alpha chain, erythrocyte|spectrin, alpha, erythrocytic 1
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Interactome
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Disease
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