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Last updated: 2021/8/8

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SPTA1 monoclonal antibody, clone AFGF-19 

  • Catalog # : MAB22243
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human SPTA1.
  • Immunogen:
  • A synthetic peptide corresponding to human SPTA1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with humant SPTA1, in native form and recombinant. Superfamily members of SPTA1 are not reactive to this antibody.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:200)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C for one year.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of SPTA1 in K-562 cell lysate.
  • Immunohistochemistry
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 6708
  • Gene Name:
  • SPTA1
  • Gene Alias:
  • EL2,SPTA
  • Gene Description:
  • spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
  • Gene Summary:
  • Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000021115,alpha-I spectrin,erythrocyte alpha-spectrin,erythroid alpha-spectrin,spectrin alpha chain, erythrocyte,spectrin, alpha, erythrocytic 1
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