PRKCH monoclonal antibody, clone ADAH-16
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of PRKCH in MCF-7 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PRKCH.
Immunogen
A synthetic peptide corresponding to human PRKCH.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with humant PRKCH, in native form and recombinant. Superfamily members of PRKCH are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of PRKCH in MCF-7 cell lysate.Immunoprecipitation
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Gene Info — PRKCH
Entrez GeneID
5583Protein Accession#
P24723Gene Name
PRKCH
Gene Alias
MGC26269, MGC5363, PKC-L, PKCL, PRKCL, nPKC-eta
Gene Description
protein kinase C, eta
Gene Ontology
HyperlinkGene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq
Other Designations
protein kinase C eta type
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Interactome
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Pathway
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Disease
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