GRIA2 monoclonal antibody, clone ACIB-7
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of Lane 1: Human fetal brain lysate; Lane 2: Mouse brain lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human GRIA2.
Immunogen
A synthetic peptide corresponding to human GRIA2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
The antibody reacts with human, mouse GRIA2, in native form and recombinant. Superfamily members of GRIA2 are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of Lane 1: Human fetal brain lysate; Lane 2: Mouse brain lysate.Immunocytochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — GRIA2
Entrez GeneID
2891Protein Accession#
P42262Gene Name
GRIA2
Gene Alias
GLUR2, GLURB, GluR-K2, HBGR2
Gene Description
glutamate receptor, ionotropic, AMPA 2
Omim ID
138247Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000165324|gluR-B|glutamate receptor 2
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Interactome
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Pathway
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Disease
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