COIL monoclonal antibody, clone AFDC-3
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human COIL.
Immunogen
A synthetic peptide corresponding to human COIL.
Host
Rabbit
Reactivity
Human
Specificity
The antibody reacts with human COIL, in native form and recombinant. Superfamily members of COIL are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:100)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate.Flow Cytometry
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Gene Info — COIL
Entrez GeneID
8161Protein Accession#
P38432Gene Name
COIL
Gene Alias
CLN80, p80-coilin
Gene Description
coilin
Omim ID
600272Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq
Other Designations
coilin p80
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Interactome
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Disease
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