ABCD3 monoclonal antibody, clone AFAF-1
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human ABCD3.
Immunogen
A synthetic peptide corresponding to human ABCD3.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with human, mouse, rat ABCD3, in native form and recombinant. Superfamily members of ABCD3 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of HepG2 cell lysate. -
Gene Info — ABCD3
Entrez GeneID
5825Protein Accession#
P28288Gene Name
ABCD3
Gene Alias
ABC43, PMP70, PXMP1
Gene Description
ATP-binding cassette, sub-family D (ALD), member 3
Omim ID
170995Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family D, member 3|OTTHUMP00000012428|Peroxisomal membrane protein-1 (70kD)|dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))|peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
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Interactome
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Disease
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