SPRY2 monoclonal antibody, clone AFOH-19
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of HeLa cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human SPRY2.
Immunogen
A synthetic peptide corresponding to human SPRY2.
Host
Rabbit
Reactivity
Human, Rat
Specificity
This antibody reacts with human, rat SPRY2, in native form and recombinant. Superfamily members of SPRY2 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of HeLa cell lysate. -
Gene Info — SPRY2
Entrez GeneID
10253Protein Accession#
O43597Gene Name
SPRY2
Gene Alias
MGC23039, hSPRY2
Gene Description
sprouty homolog 2 (Drosophila)
Omim ID
602466Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq
Other Designations
OTTHUMP00000018543|OTTHUMP00000018544|sprouty 2
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Interactome
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Pathway
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Disease
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