TXNRD1 monoclonal antibody, clone ACCE-20
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More Files
- More Functions
Western Blot
Western Blot analysis of (1) Jurkat cell lysate, (2) NIH/3T3 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human TXNRD1.
Immunogen
A synthetic peptide corresponding to human TXNRD1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody reacts with human, mouse, rat TXNRD1, in native form and recombinant. Superfamily members of TXNRD1 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) Jurkat cell lysate, (2) NIH/3T3 cell lysate. -
Gene Info — TXNRD1
Entrez GeneID
7296Protein Accession#
Q16881Gene Name
TXNRD1
Gene Alias
GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR
Gene Description
thioredoxin reductase 1
Omim ID
601112Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq
Other Designations
KM-102-derived reductase-like factor|oxidoreductase|thioredoxin reductase GRIM-12
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Interactome
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Pathway
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Disease
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