KPNA2 monoclonal antibody, clone AEAF-11
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More Files
- More Functions
Western Blot
Western Blot analysis of (1) HeLa cell lysate, (2) C6 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human KPNA2.
Immunogen
A synthetic peptide corresponding to human KPNA2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody reacts with human, mouse, rat KPNA2, in native form and recombinant. Superfamily members of KPNA2 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:1000-5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) HeLa cell lysate, (2) C6 cell lysate. -
Gene Info — KPNA2
Entrez GeneID
3838Protein Accession#
P52292Gene Name
KPNA2
Gene Alias
IPOA1, QIP2, RCH1, SRP1alpha
Gene Description
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Omim ID
600685Gene Ontology
HyperlinkGene Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
Other Designations
RAG cohort 1|importin alpha 1|importin alpha 2|importin-alpha-P1|karyopherin alpha 2|pendulin
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Interactome
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Disease
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