MBD2 monoclonal antibody, clone ADIH-13
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of A-375 cell lysate.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human MBD2.
Immunogen
A synthetic peptide corresponding to human MBD2.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with mouse, rat MBD2, in native form and recombinant. Superfamily members of MBD2 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of A-375 cell lysate. -
Gene Info — MBD2
Entrez GeneID
8932Protein Accession#
Q9UBB5Gene Name
MBD2
Gene Alias
DKFZp586O0821, DMTase, NY-CO-41
Gene Description
methyl-CpG binding domain protein 2
Omim ID
603547Gene Ontology
HyperlinkGene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq
Other Designations
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Interactome
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Disease
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