XRCC1 monoclonal antibody, clone ABOH-24
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic protein of human XRCC1.
Immunogen
A synthetic peptide corresponding to human XRCC1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody reacts with human, mouse, rat XRCC1, in native form and recombinant. Superfamily members of XRCC1 are not reactive to antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-200)
Immunofluorescence (1:50-200)
Immunocytochemistry (1:50-200)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of HeLa cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunofluorescence
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Gene Info — XRCC1
Entrez GeneID
7515Protein Accession#
P18887Gene Name
XRCC1
Gene Alias
RCC
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 1
Omim ID
194360Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Other Designations
DNA repair protein XRCC1|X-ray repair cross complementing protein 1|X-ray-repair, complementing defective, repair in Chinese hamster
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Interactome
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Pathway
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Disease
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