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Last updated: 2019/12/1

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RAD50 monoclonal antibody, clone ACCG-18 

  • Catalog # : MAB22022
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic protein of human RAD50.
  • Immunogen:
  • A synthetic peptide corresponding to human RAD50.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • A synthesized peptide derived from human Rad50 Component of the MRN complex.
  • Form:
  • Liquid
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:50-200)
    Western Blot (1:500-2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western Blot analysis of RAD50.
  • Immunofluorescence
  • Application Image
  • Immunofluorescence
  • Gene Information
  • Gene Name:
  • RAD50
  • Gene Alias:
  • RAD50-2,hRad50
  • Gene Description:
  • RAD50 homolog (S. cerevisiae)
  • Gene Summary:
  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000065928,RAD50 homolog
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